Both depression and substance use problems have their highest incidence during youth (ie,
adolescence and emerging adulthood), and are characterized by emotion regulation …

Recent interest has emerged in understanding the neural mechanisms by which deficits in
emotion regulation (ER) early in development may relate to later depression. Corticolimbic …

Background There is growing interest in understanding the neurobiology of major
depressive disorder (MDD) in youth, particularly in the context of neuroimaging studies. This …

There is substantial evidence for behavioral sex differences in risk trajectories for alcohol
and substance use, with internalizing factors such as negative affectivity contributing more to …

The cognitive regulation of emotion is impaired in major depressive disorder and has been
linked to an imbalance of pre-frontal–subcortical brain activity. Despite suggestions that this …

Objective: The neural changes underlying response to antidepressant treatment in
adolescents are unknown. Identification of neural change correlates of treatment response …

Up to 50% of youth with depression do not respond to conventional first-line treatments.
However, little research has been conducted on the pathophysiology of youth depression …

Depression is a leading cause of disability worldwide (Mathers & Loncar, 2006; World
Health Organization, 2012). Adolescent depression is especially concerning due to its …

Objective Impairments in cognitive emotion regulation (CER) have been linked to functional
neural abnormalities and the pathogenesis of major depressive disorder (MDD). Few …

Adolescence is a period marked by increases in risk taking, sensation seeking, and emotion
dysregulation. Neurobiological models of adolescent development propose that lagging …