Background Seed location filtering is critical in DNA read mapping, a process where billions
of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to …

We present Masai, a read mapper representing the state-of-the-art in terms of speed and
accuracy. Our tool is an order of magnitude faster than RazerS 3 and mrFAST, 2–4 times …

Read alignment is an ongoing challenge for the analysis of data from sequencing
technologies. This article proposes an elegantly simple multi-seed strategy, called seed-and …

Motivation High throughput DNA sequencing (HTS) technologies generate an excessive
number of small DNA segments-called short reads-that cause significant computational …

High-volume sequencing of DNA and RNA is now within reach of any research laboratory
and is quickly becoming established as a key research tool. In many workflows, each of the …

DNA sequencing data continue to progress toward longer reads with increasingly lower
sequencing error rates. We focus on the critical problem of mapping, or aligning, low …

When choosing a read mapper, one faces the trade off between speed and the ability to map
reads in highly polymorphic regions. Here, we report NextGenMap, a fast and accurate read …

Read mapping is a fundamental step in many genomics applications. It is used to identify
potential matches and differences between fragments (called reads) of a sequenced …

Read mapping is a fundamental, yet computationally-expensive step in many genomics
applications. It is used to identify potential matches and differences between fragments …

Recent advances in sequencing technology have enabled the rapid generation of billions of
bases at relatively low cost. A crucial first step in many sequencing applications is to map …