Loop regions of polypeptide in homologous proteins may be classified into structural
families. A method is described by which this classification may be performed automatically …

A computer-based algorithm was used to cluster the loops forming the complementarity
determining region (CDR) 3 of the heavy chain (H3) into canonical classes. Previous …

Conformational clusters and consensus sequences for protein loops have been derived by
computational analysis of their structures in a non-redundant set of 233 proteins with less …

One approach to finding the conformation of minimum energy for a complicated molecule is
to perform energy minimization, perhaps coupled to more exhaustive search procedures …

To be of any value, a predicted model of an antibody combining site should have an
accuracy approaching that of antibody structures determined by x-ray crystallography (1.6 …

An approach to loop prediction that starts with a database search is presented and
analyzed. To obtain meaningful statistics, 130 loops from 21 proteins were studied. The …

Each of the six CDRs of Gloop2 is shown with the modeled structure in. Overall, the results
obtained using the combined algorithm are similar in accuracy to those achieved using the …

Previous analyses of the complementarity-determining regions (CDRs) of antibodies have
focused on a small number of “canonical” conformations for each loop. This is primarily the …

Using database screening techniques we have examined the relationship between antigen‐
binding loops in immunoglobulins, and regions of similar conformation in other protein …

Grafting the antigen-binding loops onto a human antibody scaffold is a widely used
technique to humanise murine antibodies. The success of this approach depends largely on …