Do firms underinvest in long-term research? Evidence from cancer clinical trials

E Budish, BN Roin, H Williams - American Economic Review, 2015 - aeaweb.org
We investigate whether private research investments are distorted away from long-term
projects. Our theoretical model highlights two potential sources of this distortion: short …

Public R&D investments and private-sector patenting: evidence from NIH funding rules

P Azoulay, JS Graff Zivin, D Li… - The Review of economic …, 2019 - academic.oup.com
We quantify the impact of scientific grant funding at the National Institutes of Health (NIH) on
patenting by pharmaceutical and biotechnology firms. Our article makes two contributions …

Does public scientific research complement private investment in research and development in the pharmaceutical industry?

AA Toole - The Journal of Law and Economics, 2007 - journals.uchicago.edu
This paper analyzes how pharmaceutical research and development (R&D) investment
responds to publicly supported biomedical research performed mainly at universities and …

The applied value of public investments in biomedical research

D Li, P Azoulay, BN Sampat - Science, 2017 - science.org
Scientists and policy-makers have long argued that public investments in science have
practical applications. Using data on patents linked to US National Institutes of Health (NIH) …

How do patents affect research investments?

HL Williams - Annual Review of Economics, 2017 - annualreviews.org
Although patent systems have been widely used both historically and internationally, there is
nonetheless a tremendous amount of controversy over whether patent systems, in practice …

What are the respective roles of the public and private sectors in pharmaceutical innovation?

BN Sampat, FR Lichtenberg - Health affairs, 2011 - healthaffairs.org
What are the respective roles of the public and private sectors in drug development? This
question is at the heart of some policy proposals, such as those that would give the …

The vertical chain of research and development in the pharmaceutical industry

MR Ward, D Dranove - Economic inquiry, 1995 - Wiley Online Library
This paper examines the relationship between basic and applied pharmaceutical research.
We focus on three stages of research and development (R & D): government‐funded basic …

Financing biomedical innovation

AW Lo, RT Thakor - Annual Review of Financial Economics, 2022 - annualreviews.org
We review the recent literature on financing biomedical innovation, with a specific focus on
the drug development process and how it may be enhanced to improve outcomes. We begin …

Do research subsidies crowd out private R&D of large firms? Evidence from European Framework Programmes

F Szücs - Research Policy, 2020 - Elsevier
We evaluate whether public research subsidies are complements or substitutes to the
private R&D spending of large firms. Combining data on the EC's three most recent …

Shareholder returns and the exploration–exploitation dilemma: R&D announcements by biotechnology firms

P Mc Namara, C Baden-Fuller - Research Policy, 2007 - Elsevier
We explore a financial returns dimension of the exploration–exploitation dilemma. Using
1277 R&D announcements by 178 listed bio-pharmaceutical firms, we examine whether …