Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …

The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …

Currently available single-cell omics technologies capture many unique features with
different biological information content. Data integration aims to place cells, captured with …

The development of single-cell multimodal assays provides a powerful tool for investigating
multiple dimensions of cellular heterogeneity, enabling new insights into development …

Spatial transcriptomics and proteomics provide complementary information that
independently transformed our understanding of complex biological processes. However …

Deciphering the functional interactions of cells in tissues remains a major challenge. Here
we describe DIALOGUE, a method to systematically uncover multicellular programs (MCPs) …

To understand a tumor's response to a drug, researchers must study more than the tumor
itself. They must look at the microenvironment, the interplay between cancer and stroma …

Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

Highlights•Cells in tissues operate in structured microenvironments.•Studying division of
labor in tissues requires spatially-resolved transcriptomics.•This is enabled by highly …

Formalin-fixed paraffin embedding (FFPE) is the most widespread long-term tissue
preservation approach. Here, we report a procedure to perform genome-wide spatial …