Macrophages exhibit a spectrum of activation states ranging from classical to alternative
activation. Alternatively, activated macrophages are involved in diverse pathophysiological …

Macrophages play pivotal roles in both the induction and resolution phases of inflammatory
processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an …

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1)
macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

Newly activated CD8+ T cells reprogram their metabolism to meet the extraordinary
biosynthetic demands of clonal expansion; however, the signals that mediate metabolic …

Metabolic reprogramming plays a critical role in the important cellular metabolic alterations
that occur during the activation of immune cells to enable them to adapt to the extracellular …

Macrophages are not only essential components of innate immunity that contribute to host
defense against infections, but also tumor growth and the maintenance of tissue …

There is a growing appreciation for a fundamental connection between lipid metabolism and
the immune response. Macrophage phagocytosis is a signature innate immune response to …