Interaction of nanoparticles with immunocompetent cells: nanosafety considerations

D Boraschi, L Costantino, P Italiani - Nanomedicine, 2012 - Taylor & Francis
Intentional delivery of high doses of nanoparticle-based drugs or diagnostic/imaging
systems sets a new scenario in safety evaluation, compared with the environmentally borne …

Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications

B Fadeel, AE Garcia-Bennett - Advanced drug delivery reviews, 2010 - Elsevier
The development of nanoparticles for biomedical applications including medical imaging
and drug delivery is currently undergoing a dramatic expansion. However, as the range of …

Current understanding of interactions between nanoparticles and the immune system

MA Dobrovolskaia, M Shurin, AA Shvedova - Toxicology and applied …, 2016 - Elsevier
The delivery of drugs, antigens, and imaging agents benefits from using nanotechnology-
based carriers. The successful translation of nanoformulations to the clinic involves thorough …

Safety assessment of nanomaterials: implications for nanomedicine

AM Nyström, B Fadeel - Journal of controlled release, 2012 - Elsevier
Nanotechnologies offer exciting opportunities for targeted drug delivery which is anticipated
to increase the efficacy of the drug and reduce potential side-effects, through the reduction of …

Interaction of nanoparticles with blood components and associated pathophysiological effects

GG De La Cruz, P Rodríguez-Fragoso… - Unraveling the safety …, 2018 - books.google.com
Nanotechnology currently plays a pivotal role in several fields and has enabled substantial
advances in a relatively short time. In biomedicine, nanomaterials can be potentially …

Immunological properties of engineered nanomaterials

MA Dobrovolskaia, SE McNeil - Nature nanotechnology, 2007 - nature.com
Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles
that enter the body accidentally. There has been much less research on the toxicology of …

Safety of nanoparticles in medicine

J Wolfram, M Zhu, Y Yang, J Shen, E Gentile… - Current drug …, 2015 - ingentaconnect.com
Nanomedicine involves the use of nanoparticles for therapeutic and diagnostic purposes.
During the past two decades, a growing number of nanomedicines have received regulatory …

Biomedical nanoparticles: overview of their surface immune-compatibility

O Gamucci, A Bertero, M Gagliardi, G Bardi - Coatings, 2014 - mdpi.com
Diagnostic-and therapeutic release-aimed nanoparticles require the highest degree of
biocompatibility. Some physical and chemical characteristics of such nanomaterials are …

Determining the relationship between nanoparticle characteristics and immunotoxicity: key challenges and approaches

CAW David, A Owen, NJ Liptrott - Nanomedicine, 2016 - Taylor & Francis
The growing wealth of information regarding the influence that physicochemical
characteristics play on nanoparticle biocompatibility and safety is allowing improved design …

Regulatory safety evaluation of nanomedical products: key issues to refine

WH De Jong, RE Geertsma, G Borchard - Drug delivery and translational …, 2022 - Springer
Nanotechnologies enable great opportunities for the development and use of innovative
(nano) medicine s. As is common for scientific and technical developments, recognized …