[HTML][HTML] Human transcriptomic response to the VSV-vectored Ebola vaccine

F Santoro, A Donato, S Lucchesi, S Sorgi, A Gerlini… - Vaccines, 2021 - mdpi.com
Ebolavirus Disease (EVD) is a severe haemorrhagic fever that occurs in epidemic
outbreaks, with a high fatality rate and no specific therapies available. rVSVΔG-ZEBOV-GP …

[HTML][HTML] Transcriptomic signatures induced by the Ebola virus vaccine rVSVΔG-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular …

E Vianello, P Gonzalez-Dias, S van Veen… - The Lancet …, 2022 - thelancet.com
Background A recombinant vesicular stomatitis virus vector expressing the Zaire Ebola virus
glycoprotein (rVSVΔG-ZEBOV-GP) vaccine has been reported as safe, immunogenic, and …

[HTML][HTML] Correlates of vaccine-induced protective immunity against Ebola virus disease

D Medaglini, F Santoro, CA Siegrist - Seminars in immunology, 2018 - Elsevier
Ebola virus disease is a deadly infection which occurs in sporadic outbreaks. Several
vaccine candidates have been developed. The most advanced candidate is the recombinant …

[HTML][HTML] Refined innate plasma signature after rVSVΔG-ZEBOV-GP immunization is shared among adult cohorts in Europe and North America

PA Martinez-Murillo, A Huttner, S Lemeille… - Frontiers in …, 2024 - frontiersin.org
Background During the last decade Ebola virus has caused several outbreaks in Africa. The
recombinant vesicular stomatitis virus-vectored Zaire Ebola (rVSVΔG-ZEBOV-GP) vaccine …

A dose-dependent plasma signature of the safety and immunogenicity of the rVSV-Ebola vaccine in Europe and Africa

A Huttner, C Combescure, S Grillet, MC Haks… - Science translational …, 2017 - science.org
The 2014–2015 Ebola epidemic affected several African countries, claiming more than
11,000 lives and leaving thousands with ongoing sequelae. Safe and effective vaccines …

Next-generation sequencing reveals a controlled immune response to Zaire Ebola virus challenge in cynomolgus macaques immunized with vesicular stomatitis virus …

F Barrenas, RR Green, MJ Thomas… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
Vesicular stomatitis virus expressing Zaire Ebola virus (EBOV) glycoprotein
(VSVΔG/EBOVgp) could be used as a vaccine to meet the 2014 Ebola virus outbreak. To …

[HTML][HTML] Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine

D Medaglini, CA Siegrist - Current opinion in virology, 2017 - Elsevier
Highlights•An effective Ebola vaccine would be of critical importance for preventing the
disease in high risk areas.•rVSV-ZEBOV is the only Ebola vaccine with demonstrated …

[HTML][HTML] Dose-dependent T-cell dynamics and cytokine cascade following rVSV-ZEBOV immunization

C Dahlke, R Kasonta, S Lunemann, V Krähling… - …, 2017 - thelancet.com
Abstract Background The recent West African Ebola epidemic led to accelerated efforts to
test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola …

Antiviral innate responses induced by VSV-EBOV vaccination contribute to rapid protection

AR Menicucci, A Jankeel, H Feldmann, A Marzi… - MBio, 2019 - Am Soc Microbiol
Ebola virus (EBOV) is a single-stranded RNA virus that causes Ebola virus disease (EVD),
characterized by excessive inflammation, lymphocyte apoptosis, hemorrhage, and …

[HTML][HTML] Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4

CY Lai, DP Strange, TAS Wong, AT Lehrer… - Frontiers in …, 2017 - frontiersin.org
Ebola virus (EBOV), a member of the Filoviridae family, causes the most severe form of viral
hemorrhagic fever. Although no FDA licensed vaccine or treatment against Ebola virus …