To provide insights into the biology of opioid dependence (OD) and opioid use (ie,
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …

Despite the large toll of opioid use disorder (OUD), genome-wide association studies
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale …

Background We report a genome-wide association study (GWAS) of two populations, African-
American and European-American (AA, EA) for opioid dependence (OD) in three sets of …

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD …

Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

Background Opioid dependence (OD) is at epidemic levels in the United States. Genetic
studies can provide insight into its biology. Methods We completed an OD genome-wide …

Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in
OPRM1, has been identified as a genome-wide significant association with OA and …

Highlights•Opioid use disorder risk has a large heritable component (23–54%).•The OPRM1
variant rs1799971 (aka A118G) as a small effect on risk for OUD and general substance …

Opioids are very effective analgesics, but they are also highly addictive. Methadone is used
to treat opioid dependence (OD), acting as a selective agonist at the μ-opioid receptor …

Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small
nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one …