Background: Alzheimer's disease is one of the most common mental illnesses. It is posited
that more than 25% of the population is affected by some mental disease during their …

Introduction Alzheimer's disease (AD) is a slowly progressing neurodegenerative brain
disease with irreversible brain effects; it is the most common cause of dementia. With …

Alzheimer's disease is a complex, multi-factorial, and multi-parametric neurodegenerative
etiology. Mathematical models can help understand such a complex problem by providing a …

Introduction Several advances have been made in Alzheimer's Disease (AD) modeling,
however, there remains a need for a simulator that represents the full scope of disease …

In the coming decades, the size and age-structure of Europe's population will undergo
dramatic changes due to low fertility rates and continuous increases in life expectancy …

SimulAD is a computational disease progression model (DPM) originally developed on the
ADNI database to simulate the evolution of clinical and imaging markers characteristic of …

Introduction: During a creation of an agent based simulation is important to choose
appropriate tools suitable for simulated topic. Large scale agent based simulations with a …

Alzheimer's disease (AD) is the most common neurodegenerative aging disorder affecting
millions of individual worldwide. AD is associated with memory decline as well as …

Background Given the increasing lifespan of the elderly and the higher proportion of older
people in the global population, the incidence rate of neurodegenerative diseases is …

Population distribution has already changed in the last decades and will undergo further
changes in the near future due to the so called “double aging” effect. This is an important …