Liver fat accumulation is associated with circulating PCSK9

M Ruscica, N Ferri, C Macchi, M Meroni, C Lanti… - Annals of …, 2016 - Taylor & Francis
Background: Nonalcoholic fatty liver disease (NAFLD) associates with cardiovascular
disease independently of classic risk factors. Proprotein Convertase Subtilisin/Kexin type 9 …

Circulating PCSK9 is associated with liver biomarkers and hepatic steatosis

M Paquette, D Gauthier, A Chamberland, A Prat… - Clinical …, 2020 - Elsevier
Background In parallel to the increasing prevalence of metabolic syndrome, the prevalence
of hepatic steatosis has also increased dramatically worldwide. Hepatic steatosis is a major …

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population

M Wargny, PH Ducluzeau, JM Petit, C Le May, S Smati… - Atherosclerosis, 2018 - Elsevier
Background and aims Some studies suggested that proprotein convertase subtilisin kexin
type 9 (PCSK9) is linked to liver steatosis severity and non-alcoholic steatohepatitis (NASH) …

High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes

K Németh, B Tóth, F Sarnyai, A Koncz, D Lenzinger… - Nutrition & …, 2023 - Springer
Background High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a
serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in …

The role of PCSK9 in the pathogenesis of non-alcoholic fatty liver disease and the effect of PCSK9 inhibitors

E Theocharidou, M Papademetriou… - Current …, 2018 - ingentaconnect.com
Background: Statin treatment exhibits a beneficial effect on non-alcoholic fatty liver disease
(NAFLD) and on cardiovascular disease (CVD) in patients with NAFLD. Objective: The aim …

Hepatic and circulating levels of PCSK9 in morbidly obese patients: Relation with severity of liver steatosis

MR Emma, L Giannitrapani, D Cabibi, R Porcasi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is becoming the main cause of liver disease in
Western countries, especially in morbidly obese patients (MOPs). The proprotein convertase …

PCSK9 rs11591147 R46L loss‐of‐function variant protects against liver damage in individuals with NAFLD

S Grimaudo, S Bartesaghi, R Rametta… - Liver …, 2021 - Wiley Online Library
Abstract Background and Aims The proprotein convertase subtilisin/kexin type 9 (PCSK9)
plays a key role in cholesterol homeostasis, and its inhibition represents an effective therapy …

The role of PCSK9 in NAFLD/NASH and therapeutic implications of PCSK9 inhibition

AA Momtazi-Borojeni, M Banach… - Expert Review of …, 2022 - Taylor & Francis
Introduction There are inconsistent findings regarding the effect of lipid-lowering agents on
nonalcoholic fatty liver disease (NAFLD). Proprotein Convertase Subtilisin/Kexin type 9 …

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

P Dongiovanni, M Meroni, G Baselli, RM Mancina… - Journal of lipid …, 2019 - ASBMB
Dyslipidemia and altered iron metabolism are typical features of nonalcoholic fatty liver
disease (NAFLD). Proprotein convertase subtilisin/kexin type 7 (PCSK7) gene variation has …

Analysis of steatosis biomarkers and inflammatory profile after adding on PCSK9 inhibitor treatment in familial hypercholesterolemia subjects with nonalcoholic fatty …

R Scicali, A Di Pino, F Urbano, V Ferrara… - Nutrition, Metabolism …, 2021 - Elsevier
Background and aims Nonalcoholic fatty liver disease (NAFLD) may be crucial in subjects
with familial hypercholesterolemia (FH). We aimed to evaluate the effect of the inhibitors of …