Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

C Qiu, S Huang, J Park, YS Park, YA Ko, MJ Seasock… - Nature medicine, 2018 - nature.com
Chronic kidney disease (CKD), a condition in which the kidneys are unable to clear waste
products, affects 700 million people globally. Genome-wide association studies (GWASs) …

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments

X Sheng, Y Guan, Z Ma, J Wu, H Liu, C Qiu, S Vitale… - Nature …, 2021 - nature.com
The functional interpretation of genome-wide association studies (GWAS) is challenging due
to the cell-type-dependent influences of genetic variants. Here, we generated …

New loci associated with kidney function and chronic kidney disease

A Köttgen, C Pattaro, CA Böger, C Fuchsberger… - Nature …, 2010 - nature.com
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Multiple loci associated with indices of renal function and chronic kidney disease

A Köttgen, NL Glazer, A Dehghan, SJ Hwang, R Katz… - Nature …, 2009 - nature.com
Chronic kidney disease (CKD) has a heritable component and is an important global public
health problem because of its high prevalence and morbidity. We conducted genome-wide …

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease

H Liu, T Doke, D Guo, X Sheng, Z Ma, J Park, HMT Vy… - Nature …, 2022 - nature.com
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

Genetic-variation-driven gene-expression changes highlight genes with important functions for kidney disease

YA Ko, H Yi, C Qiu, S Huang, J Park, N Ledo… - The American Journal of …, 2017 - cell.com
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

X Xu, JM Eales, A Akbarov, H Guo, L Becker… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …

Insights into kidney diseases from genome-wide association studies

M Wuttke, A Köttgen - Nature Reviews Nephrology, 2016 - nature.com
Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals

KJ Stanzick, Y Li, P Schlosser, M Gorski… - Nature …, 2021 - nature.com
Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …