Administration of activated protein C (APC) protects from renal dysfunction, but the
underlying mechanism is unknown. APC exerts both antithrombotic and cytoprotective …

Acute renal failure, a serious condition characterised by a drastic decline in renal function,
often follows ischaemia/reperfusion (I/R) episodes. I/R is characterised by necrosis …

Protein C is a plasma serine protease that when activated plays a central role in modulating
the function of the vascular endothelium and its interface with the innate immune system …

Endothelial dysfunction contributes significantly to acute renal failure (ARF) during
inflammatory diseases including septic shock. Previous studies have shown that activated …

Activated protein C (APC) has anti-inflammatory and vascular protective effects independent
of anticoagulation. We previously identified the prototypical thrombin receptor, protease …

Activated protein C (APC) reduces mortality of severe sepsis patients but increases the risk
of serious bleeding. APC exerts anticoagulant activity by proteolysis of factors Va/VIIIa. APC …

We examined whether activated protein C (APC) reduces ischemia/reperfusion (I/R)–
induced renal injury by inhibiting leukocyte activation. In a rat model, intravenous …

Activated protein C (APC) has been reported to improve survival in patients with severe
sepsis. 1 Protein C (PC) is physiologically activated on the endothelial cell surface by the …

The direct cytoprotective activities of activated protein C (APC) on cells convey therapeutic,
relevant, beneficial effects in injury and disease models in vivo and require the endothelial …

The protein C pathway provides multiple important functions to maintain a regulated balance
between hemostasis and host defense systems in response to vascular and inflammatory …