BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases

MJ Hoenerhoff, I Chu, D Barkan, ZY Liu, S Datta… - Oncogene, 2009 - nature.com
B-lymphoma Moloney murine leukaemia virus insertion region-1 (BMI1) is a member of the
polycomb group of transcription repressors, which functions in stem cell maintenance and …

Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

BH Guo, Y Feng, R Zhang, LH Xu, MZ Li, HF Kung… - Molecular cancer, 2011 - Springer
Background B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as
an oncogene in various tumors, and its overexpression correlates with a poor outcome in …

BMI‐1 promotes breast cancer proliferation and metastasis through different mechanisms in different subtypes

J Liu, Y Jiang, H Huang, J Xu, Y Wu, Q Wang… - Cancer …, 2023 - Wiley Online Library
Breast cancer is among the most common malignant cancers in women. B‐cell‐specific
Moloney murine leukemia virus integration site 1 (BMI‐1) is a transcriptional repressor that …

Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast …

Z Xu, H Liu, X Lv, Y Liu, S Li, H Li - Oncology reports, 2011 - spandidos-publications.com
It is well documented that B cell-specific Moloney murine leukemia virus integration site 1
(Bmi-1), widely overexpressed in the vast majority of malignancies, plays an essential role in …

Bmi‐1 is related to proliferation, survival and poor prognosis in pancreatic cancer

W Song, K Tao, H Li, C Jin, Z Song, J Li, H Shi… - Cancer …, 2010 - Wiley Online Library
B‐cell‐specific Moloney murine leukemia virus insertion site 1 (BMI1) is a member of the
polycomb group of transcriptional repressors. Until now, its expression and functional …

Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways

S Datta, MJ Hoenerhoff, P Bommi, R Sainger, WJ Guo… - Cancer research, 2007 - AACR
Elevated expression of Bmi-1 is associated with many cancers, including breast cancer.
Here, we examined the oncogenic potential of Bmi-1 in MCF10A cells, a spontaneously …

Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis

CR Xu, S Lee, C Ho, P Bommi, SA Huang… - Molecular Cancer …, 2009 - AACR
Bmi1 is a polycomb group proto-oncogene that has been implicated in multiple tumor types.
However, its role in hepatocellular carcinoma (HCC) development has not been well …

shRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and metastasis

X Meng, Y Wang, X Zheng, C Liu, B Su, H Nie, B Zhao… - Lung cancer, 2012 - Elsevier
Bmi-1 has been implicated in cancer cell growth and metastasis in a variety of tumor types.
In this study, we sought to evaluate the expression of Bmi-1 in lung adenocarcinoma …

[HTML][HTML] Downregulation of Bmi1 in breast cancer stem cells suppresses tumor growth and proliferation

M Srinivasan, DJ Bharali, T Sudha, M Khedr, I Guest… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Targeting cancer stem cells during initial treatment is important to reduce incidence of
recurrent disease. Bmi1 has been associated with cancer stem cell self-renewal and …

A novel aspect of tumorigenesis—BMI1 functions in regulating DNA damage response

X Lin, D Ojo, F Wei, N Wong, Y Gu, D Tang - Biomolecules, 2015 - mdpi.com
BMI1 plays critical roles in maintaining the self-renewal of hematopoietic, neural, intestinal
stem cells, and cancer stem cells (CSCs) for a variety of cancer types. BMI1 promotes cell …