Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in α4-and protein phosphatase 2A-dependent fashion

JA Fielhaber, YS Han, J Tan, S Xing, CM Biggs… - Journal of Biological …, 2009 - ASBMB
Target of rapamycin (TOR) is a highly conserved serine/threonine kinase that controls cell
growth, primarily via regulation of protein synthesis. In Saccharomyces cerevisiae, TOR can …

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast

K Düvel, A Santhanam, S Garrett, L Schneper… - Molecular cell, 2003 - cell.com
Tor proteins, targets of the antiinflammatory drug rapamycin, mediate a conserved signaling
pathway required for cell growth and proliferation in eukaryotes. By global transcriptional …

mTOR binds to the promoters of RNA polymerase I-and III-transcribed genes

CK Tsang, H Liu, XFS Zheng - Cell Cycle, 2010 - Taylor & Francis
Target of rapamycin (TOR) is a conserved regulator of gene expression from yeast to
humans. In budding yeast, TOR is associated with ribosomal DNA (rDNA) promoter, which is …

TOR-in (g) the nucleus

CK Tsang, XFS Zheng - Cell Cycle, 2007 - Taylor & Francis
Target of rapamycin (TOR) is a central component of the eukaryotic growth regulatory
network. TOR controls the expression of diverse genes by all three RNA polymerases …

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

MN Corradetti, K Inoki, KL Guan - Journal of Biological Chemistry, 2005 - ASBMB
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that plays an
essential role in cell growth control. mTOR stimulates cell growth by phosphorylating p70 …

Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by …

AS Kristof, J Marks-Konczalik, E Billings… - Journal of Biological …, 2003 - ASBMB
Mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) regulate
cell growth, protein synthesis, and apoptosis in response to nutrients and mitogens. As an …

Protein phosphorylation as a key mechanism of mTORC1/2 signaling pathways

E Tchevkina, A Komelkov - Protein Phosphorylation in Human …, 2012 - books.google.com
The mammalian target of rapamycin (mTOR) has attracted growing attention during the past
decade due to the increase realization of it's extraordinarily significance in cellular …

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

H Nojima, C Tokunaga, S Eguchi, N Oshiro… - Journal of Biological …, 2003 - ASBMB
The mammalian target of rapamycin (mTOR) controls multiple cellular functions in response
to amino acids and growth factors, in part by regulating the phosphorylation of p70 S6 …

Rapamycin activates Tap42‐associated phosphatases by abrogating their association with Tor complex 1

G Yan, X Shen, Y Jiang - The EMBO journal, 2006 - embopress.org
In Saccharomyces cerevisiae, the Tap42–phosphatase complexes are major targets of the
Tor kinases in the rapamycin‐sensitive signaling pathway. The immunosuppressive agent …

Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate …

F Das, N Ghosh-Choudhury, N Dey, CC Mandal… - Journal of Biological …, 2012 - ASBMB
Tuberous sclerosis complex 2 (TSC2) and phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) function to block growth factor-induced mammalian target of …