Airways are exposed to myriad environmental and damaging agents such as reactive
oxygen species (ROS), which also have physiological roles as signaling molecules that …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

The epithelium lining the airways of the adult human lung is composed of ciliated and
secretory cells together with undifferentiated basal cells (BCs). The composition and …

Organ regeneration requires dynamic cell interactions to reestablish cell numbers and tissue
architecture. While we know the identity of progenitor cells that replace lost tissue, the …

The distal lung is a honeycomb-like collection of delicate gas exchange sacs called alveoli
lined by two interspersed epithelial cell types: the cuboidal, surfactant-producing alveolar …

The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Background Despite compelling data describing pro-regenerative effects of all-trans retinoic
acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease (COPD), clinical …

While the acquisition of cellular plasticity in adult stem cells is essential for rapid
regeneration after tissue injury, little is known about the underlying mechanisms governing …

As aerobic organisms, we are continuously and throughout our lifetime subjected to an
oxidizing atmosphere and, most often, to environmental threats. The lung is the internal …

The lungs are constantly exposed to the external environment and are therefore vulnerable
to insults that can cause infection and injury. Maintaining the integrity and barrier function of …