Markers of biological aging have potential utility in primary care and public health. We
developed a model of age based on untargeted metabolic profiling across multiple …

Background Human aging is associated with profound changes in one of the major
epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …

Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Age-associated DNA methylation changes have been widely reported across many different
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Background DNA methylation (DNAm) age acceleration (AgeAccel) has been shown to be
predictive of all-cause mortality but it is unclear what functional aspect (s) of aging it …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Understanding how metabolites are longitudinally influenced by age and sex could facilitate
the identification of metabolomic profiles and trajectories that indicate disease risk. We …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …