Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1
Risk of schizophrenia is likely to involve gene× environment (G× E) interactions. Neuregulin
1 (NRG1) is a schizophrenia risk gene, hence any interaction with environmental adversity …
1 (NRG1) is a schizophrenia risk gene, hence any interaction with environmental adversity …
Animal model for schizophrenia that reflects gene-environment interactions
T Nagai, D Ibi, K Yamada - Biological and Pharmaceutical Bulletin, 2011 - jstage.jst.go.jp
Schizophrenia is a devastating psychiatric disorder that impairs mental and social
functioning and affects approximately 1% of the population worldwide. Genetic susceptibility …
functioning and affects approximately 1% of the population worldwide. Genetic susceptibility …
Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene× …
L Desbonnet, C O'Tuathaigh, G Clarke… - Brain, behavior, and …, 2012 - Elsevier
There is a paucity of animal models by which the contributions of environmental and genetic
factors to the pathobiology of psychosis can be investigated. This study examined the …
factors to the pathobiology of psychosis can be investigated. This study examined the …
Behavioral phenotypes in schizophrenic animal models with multiple combinations of genetic and environmental factors
H Hida, A Mouri, Y Noda - Journal of pharmacological sciences, 2013 - jstage.jst.go.jp
Schizophrenia is a multifactorial psychiatric disorder in which both genetic and
environmental factors play a role. Genetic [eg, Disrupted-in-schizophrenia 1 (DISC1) …
environmental factors play a role. Genetic [eg, Disrupted-in-schizophrenia 1 (DISC1) …
Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout'of the schizophrenia risk gene neuregulin-1
CMP O'Tuathaigh, AM O'Connor, GJ O'Sullivan… - Progress in Neuro …, 2008 - Elsevier
Clinical genetic studies have implicated neuregulin-1 [NRG1] as a leading susceptibility
gene for schizophrenia. NRG1 is known to play a significant role in the developing brain …
gene for schizophrenia. NRG1 is known to play a significant role in the developing brain …
Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation
AM Hemmerle, R Ahlbrand, SL Bronson… - Schizophrenia …, 2015 - Elsevier
Maternal immune activation (MIA) is an environmental risk factor for schizophrenia, and may
contribute to other developmental disorders including autism and epilepsy. Activation of pro …
contribute to other developmental disorders including autism and epilepsy. Activation of pro …
Neuregulin 1: a prime candidate for research into gene-environment interactions in schizophrenia? Insights from genetic rodent models
T Karl - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Schizophrenia is a multi-factorial disease characterized by a high heritability and
environmental risk factors. In recent years, an increasing number of researchers worldwide …
environmental risk factors. In recent years, an increasing number of researchers worldwide …
Phenotypic characterization of spatial cognition and social behavior in mice with 'knockout'of the schizophrenia risk gene neuregulin 1
CMP O'Tuathaigh, D Babovic, GJ O'Sullivan, JJ Clifford… - Neuroscience, 2007 - Elsevier
Neuregulin-1 (NRG1) has been identified as a candidate susceptibility gene for
schizophrenia. In the present study the functional role of the NRG1 gene, as it relates to …
schizophrenia. In the present study the functional role of the NRG1 gene, as it relates to …
Timing of maternal immune activation and sex influence schizophrenia-relevant cognitive constructs and neuregulin and GABAergic pathways
JP Nakamura, A Schroeder, A Gibbons… - Brain, behavior, and …, 2022 - Elsevier
Maternal immune activation (MIA) during pregnancy is an established environmental risk
factor for schizophrenia. Timing of immune activation exposure as well as sex of the …
factor for schizophrenia. Timing of immune activation exposure as well as sex of the …
Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice
TW Chohan, AA Boucher, JR Spencer… - Schizophrenia …, 2014 - academic.oup.com
Stress has been linked to the pathogenesis of schizophrenia. Genetic variation in neuregulin
1 (NRG1) increases the risk of developing schizophrenia and may help predict which high …
1 (NRG1) increases the risk of developing schizophrenia and may help predict which high …