Vaccination route dictates the quality and localization of immune responses within tissues.
Intranasal vaccination seeds tissue-resident adaptive immunity, alongside trained innate …

The nature and anatomic location of the protective memory CD8+ T cell subset induced by
intranasal vaccination remain poorly understood. We developed a vaccination model to …

Introduction Resurgence of pertussis, caused by Bordetella pertussis, necessitates novel
vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular …

Tissue-resident memory T cells (TRM) are a recently defined, noncirculating subset with the
potential for rapid in situ protective responses, although their generation and role in vaccine …

Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus
infection in animal models. In humans, the capacity of peripheral vaccination to generate …

Yearly administration of influenza vaccines is our best available tool for controlling influenza
virus spread. However, both practical and immunological factors sometimes result in sub …

Multiple SARS-CoV-2 vaccine candidates have been approved for use and have had a
major impact on the COVID-19 pandemic. There remains, however, a significant need for …

Recent evidence indicates that tissue-resident innate immune memory and trained innate
immunity (TII) can be induced centrally in myeloid cells within the bone marrow and locally …

Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies
provide the most effective protection of the lungs from viral infections. To induce those …

Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus
infection in animal models. In humans, SARS-CoV-2 immunity has been studied extensively …