Age-related frailty is an increasing societal challenge with growing emphasis on identifying
its underlying pathophysiology and prospects for intervention. We report findings from the …

Chronic systematic inflammation and reduced immune system fitness are considered
potential contributing factors to the development of age-related frailty, but the underlying …

Frailty is a term used as a marker of vulnerability, identifying individuals with a diminished
capacity to respond to external stressors. Those who are frail are at increased risk of death …

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors,
leading to a higher risk of negative health-related outcomes.“Inflammaging”, an age-related …

Introduction Ageing is associated with several physiological changes, including changes in
the immune system. Age-related changes in the innate and adaptive immune system are …

Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and
leads to an increase of the age-related decline of different physiological systems and …

Chronic low-grade elevations of blood-borne cytokines/chemokines in older age tend to
associate with frailty in humans. This persistent inflammation is often called “inflammageing” …

Frailty is a still-evolving concept of a complex phenomenon. There are several algorithms
and strategies for assessing frailty syndrome, but currently, no universally accepted …

Inflammation in patients defined as frail by Fried's phenotypic definition may be related to
sarcopenia. This study aimed to investigate inflammation in older patients across different …

The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …