Summary Mitofusin 2 (MFN2) plays critical roles in both mitochondrial fusion and the
establishment of mitochondria-endoplasmic reticulum (ER) interactions. Hypothalamic ER …

Proopiomelanocortin (POMC) neurons are critical sensors of nutrient availability implicated
in energy balance and glucose metabolism control. However, the precise mechanisms …

Low-grade mitochondrial stress can promote health and longevity, a phenomenon termed
mitohormesis. Here, we demonstrate the opposing metabolic effects of low-level and high …

Consuming a calorically dense diet stimulates microglial reactivity in the mediobasal
hypothalamus (MBH) in association with decreased number of appetite-curbing pro …

Mitochondria are key organelles in the maintenance of cellular energy metabolism and
integrity. Here, we show that mitochondria number decrease but their size increase in …

The ability of an organism to convert organic molecules from the environment into energy is
essential for the development of cellular structures, cell differentiation and growth …

Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy and glucose
metabolism. Intracellular mechanisms that enable these neurons to respond to changes in …

Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal
mitochondrial function is ensured by a quality-control system tightly coupled to fusion and …

Mitochondrial fusion and fission events, collectively known as mitochondrial dynamics, act
as quality control mechanisms to ensure mitochondrial function and fine‐tune cellular …

Significance: Mitochondrial dynamics is a complex process that impacts on mitochondrial
biology. Recent Advances: Recent evidence indicates that proteins participating in …