Autophagy is one of the main cellular catabolic pathways controlling a variety of
physiological processes, including those involved in self-renewal, differentiation and death …

Acute promyelocytic leukemia (APL) cells exhibit disrupted regulation of cell death and
differentiation, and therefore the fate of these leukemic cells is unclear. Here, we provide the …

PML-RARα oncoprotein is a fusion protein of promyelocytic leukemia (PML) and the retinoic
acid receptor-α (RARα) and causes acute promyelocytic leukemias (APL). A hallmark of all …

Retinoids are a family of signaling molecules derived from vitamin A with well established
roles in cellular differentiation. Physiologically active retinoids mediate transcriptional effects …

Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by
an abnormal PML‐RARα fusion oncoprotein, leading to a block in cell differentiation …

Abstract Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid and/or
arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs …

Autophagy is a highly conserved, closely regulated homeostatic cellular activity that allows
for the bulk degradation of long-lived proteins and cytoplasmic organelles. Its roles in cancer …

Highlights•Autophagy is increased during all-trans-retinoic acid-induced differentiation of
NB4 leukemia cells.•Inhibition (small hairpin RNA) of an essential autophagy gene ATG7 …

Autophagy is a lysosomal degradation pathway that is constitutively active in almost every
cell of our body at basal level. This self-eating process primarily serves to remove …

Despite the high efficacy and safety of arsenic trioxide (ATO) in treating acute promyelocytic
leukemia (APL) and eradicating APL leukemia-initiating cells (LICs), the mechanism …