Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by
depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic …

Rationale: Epigenetic marks are crucial for organogenesis, but their role in heart
development is poorly understood. Polycomb repressive complex 2 (PRC2) trimethylates …

Polycomb group (PcG) proteins regulate important cellular processes such as
embryogenesis, cell proliferation, and stem cell self-renewal through the transcriptional …

The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes
to maintain transcriptional programs and ensure cellular identity. PRC2 methylates lysine 27 …

The Polycomb group proteins foster gene repression profiles required for proper
development and unimpaired adulthood, and comprise the components of the Polycomb …

Abstract Polycomb repressive complex 2 (PRC2) catalyzes methylation on lysine 27 of
histone H3 (H3K27) and is required for maintaining transcriptional patterns and cellular …

Summary Polycomb Group (PcG) proteins maintain transcriptional repression throughout
development, mostly by regulating chromatin structure. Polycomb Repressive Complex 2 …

Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of
chromatin domains repressive to transcription through catalysis of methylation of histone H3 …

The maintenance of gene expression patterns during metazoan development is achieved, in
part, by the actions of polycomb repressive complex 2 (PRC2). PRC2 catalyzes mono-, di …

Abstract Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that is
critical for regulating transcriptional repression in mammals. Its catalytic subunit, EZH2, is …