Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and
intrinsic force production (quality). Along with decreased functional capacity of the muscle …

Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the
human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by …

Sarcopenia corresponds to the degenerative loss of skeletal muscle mass, quality, and
strength associated with ageing and leads to a progressive impairment of mobility and …

The potential deleterious roles of “oxidative stress” have been studied in skeletal muscle for
over 30 years, but recent studies have identified that reactive oxygen species and nitric …

As we age, our skeletal muscle becomes smaller and weaker. In addition, the remaining
muscle is more susceptible to damage, particularly following exercise, recovery from …

The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …

Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …

Long periods of skeletal muscle inactivity promote a loss of muscle protein resulting in fiber
atrophy. This disuse-induced muscle atrophy results from decreased protein synthesis and …

Muscle mass and strength are very important for exercise performance. Training-induced
musculoskeletal injuries usually require periods of complete immobilization to prevent any …