[HTML][HTML] Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate

DR Valenzano, E Terzibasi, T Genade, A Cattaneo… - Current biology, 2006 - cell.com
Resveratrol, a natural phytoalexin found in grapes and red wine [1], increases longevity in
the short-lived invertebrates Caenorhabditis elegans and Drosophila [2–5] and exerts a …

Resveratrol and the pharmacology of aging: a new vertebrate model to validate an old molecule

DR Valenzano, A Cellerino - Cell Cycle, 2006 - Taylor & Francis
The natural phytoalexin resveratrol, found in grapes and red wine, recently raised to public
fame for its positive effects on longevity in yeasts, worms and flies. Resveratrol anti-cancer …

[HTML][HTML] Lifespan and healthspan extension by resveratrol

KS Bhullar, BP Hubbard - Biochimica et Biophysica Acta (BBA)-Molecular …, 2015 - Elsevier
A number of small molecules with the ability to extend the lifespan of multiple organisms
have recently been discovered. Resveratrol, amongst the most prominent of these, has …

[HTML][HTML] A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

JL Barger, T Kayo, JM Vann, EB Arias, J Wang… - PloS one, 2008 - journals.plos.org
Resveratrol in high doses has been shown to extend lifespan in some studies in
invertebrates and to prevent early mortality in mice fed a high-fat diet. We fed mice from …

The effect of resveratrol on longevity across species: a meta-analysis

KL Hector, M Lagisz, S Nakagawa - Biology letters, 2012 - royalsocietypublishing.org
Resveratrol has shown evidence of decreasing cancer incidence, heart disease, metabolic
syndrome and neural degeneration in animal studies. However, the effects on longevity are …

Resveratrol in mammals: effects on aging biomarkers, age‐related diseases, and life span

J Marchal, F Pifferi, F Aujard - … of the New York Academy of …, 2013 - Wiley Online Library
Through its antioxidant, anticarcinogenic, and anti‐inflammatory properties, resveratrol has
become a candidate for drug development in the context of aging studies. Scientific …

Resveratrol and lifespan in model organisms

K Pallauf, G Rimbach, PM Rupp… - Current medicinal …, 2016 - ingentaconnect.com
Background: Resveratrol may possess life-prolonging and health-benefitting properties,
some of which may resemble the effect of caloric restriction (CR). CR appears to prolong the …

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

C Wang, CT Wheeler, T Alberico, X Sun, J Seeberger… - Age, 2013 - Springer
Resveratrol, a polyphenolic compound, has been shown to extend lifespan in different
organisms. Emerging evidence suggests that the prolongevity effect of resveratrol depends …

[HTML][HTML] Resveratrol preserves cerebrovascular density and cognitive function in aging mice

CA Oomen, E Farkas, V Roman… - Frontiers in aging …, 2009 - frontiersin.org
Resveratrol, a natural polyphenol abundant in grapes and red wine, has been reported to
exert numerous beneficial health effects. Among others, acute neuroprotective effects of …

[HTML][HTML] Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

KJ Pearson, JA Baur, KN Lewis, L Peshkin, NL Price… - Cell metabolism, 2008 - cell.com
A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related
diseases in laboratory animals is greatly sought after. We and others have shown that …