Herpes simplex virus (HSV) infection of the cornea culminates in an immunopathological
lesion (stromal keratitis–SK) that impairs vision. This report shows that HSV infection results …

HSV-1 infection of the cornea leads to a blinding immunoinflammatory lesion of the eye
termed stromal keratitis (SK). Recently, IL-17–producing CD4+ T cells (Th17 cells) were …

Two prominent anti-inflammatory mechanisms involved in controlling HSV-1-induced
corneal immunopathology (stromal keratitis or SK) are the production of the cytokine IL-10 …

Purpose.: Interleukin (IL)-12p40 can couple with IL-12p35 or p19 chains to form the
molecules IL-12p70 and IL-23, respectively, which promote TH 1 cytokine responses. IL …

Ocular infection with HSV causes corneal neovascularization (CV), an essential step in the
pathogenesis of the blinding immunoinflammatory lesion stromal keratitis. The infection …

We investigated whether IL-10 produced endogenously would influence the development of
HSV-1-induced acute corneal disease. Murine corneal epithelial cells and fibroblasts …

Herpetic stromal keratitis (HSK) is an immunopathologic disease triggered by infection of the
cornea with HSV. Key events in HSK involve the interaction between cornea-infiltrating …

IL-17 has been associated with selected inflammatory and autoimmune diseases. We
characterized the expression of this proinflammatory cytokine following HSV-1 corneal …

Interleukin-17 (IL-17), mainly produced by activated (memory) T cells, has been found in the
corneas from herpetic stromal keratitis (HSK) patients. To better understand the role of IL-17 …

Evidence suggests that in BALB/c mice infected with HSV-1, increased corneal scarring
correlated with the presence of IL-12p40 mRNA in the cornea. To determine if this observed …