Background Psychiatric disorders are highly heritable and polygenic, and many have their
peak onset in late childhood and adolescence, a period of tremendous changes. Although …

Psychiatric disorders are highly heritable and polygenic, and many have their peak onset in
late childhood and adolescence, a period of tremendous changes. Although the …

Background Comorbidity is the rule rather than the exception for childhood and adolescent
onset mental disorders, but we cannot predict its occurrence and do not know the neural …

Imaging genetics provides an opportunity to discern associations between genetic variants
and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; …

Background Adolescence is a key period for brain development and the emergence of
psychopathology. The Adolescent Brain Cognitive Development (ABCD) study was created …

Objective Overlap of brain changes across mental disorders has reinforced transdiagnostic
models. However, the developmental basis for this overlap is unclear as are neural …

Although there are pronounced sex differences for psychiatric disorders, relatively little has
been published on the heterogeneity of sex-specific genetic effects for these traits until very …

Objective This study examined the relation between polygenic scores (PGSs) for 5 major
psychiatric disorders and 2 cognitive traits with brain magnetic resonance imaging …

Background A child's socioeconomic environment can shape central aspects of their life,
including vulnerability to mental disorders. Negative environmental influences in youth may …

The human brain undergoes structural and functional changes during childhood, a critical
period in cognitive and behavioral development. Understanding the genetic architecture of …