Xenotransplantation is a promising strategy to alleviate the shortage of organs for human
transplantation. In addition to the concerns about pig-to-human immunological compatibility …

The shortage of organs for transplantation is a major barrier to the treatment of organ failure.
Although porcine organs are considered promising, their use has been checked by …

The practice of xenotransplantation using pig islet cells or organs is under development to
alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or …

The clinical applicability of porcine xenotransplantation—a long-investigated alternative to
the scarce availability of human organs for patients with organ failure—is limited by …

CRISPR/Cas (clustered regularly interspaced short palindromic repeats linked to Cas
nuclease) technology has revolutionized many aspects of genetic engineering research …

Transplantation of porcine xenografts into human recipients is a realistic option to overcome
the growing worldwide shortage of suitable allogeneic organs. However, there remains the …

The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Xenotransplantation of porcine organs might provide an unlimited source of donor organs to
treat endstage organ failure diseases in humans. However, pigs harbour retroviruses with …

Animal donors such as pigs could provide an alternative source of organs for
transplantation. However, the promise of xenotransplantation is offset by the possible public …