Therapeutic options for the treatment of an increasing variety of cancers have been
expanded by the introduction of a new class of drugs, commonly referred to as checkpoint …

Summary The Cancer Genome Atlas revealed the genomic landscapes of human cancers.
In parallel, immunotherapy is transforming the treatment of advanced cancers. Unfortunately …

Purpose: Throughout their development, tumors are challenged by the immune system, and
they acquire features to evade its surveillance. A systematic view of these traits, which shed …

The immune composition of the tumor microenvironment influences response and
resistance to immunotherapies. While numerous studies have identified somatic correlates …

With the recent advent of immunotherapy, there is a critical need to understand immune cell
interactions in the tumor microenvironment in both pan-cancer and tissue-specific contexts …

Over the last decade, it has become clear that the genomic landscapes of tumors profoundly
impact their immunogenicity and how tumor cells interact with immune cells. Whereas past …

To elucidate the role of immune cell infiltration as a prognostic signature in solid tumors, we
analyzed immune-function-related genes from four publicly available single-cell RNA-Seq …

Purpose: Immune checkpoint inhibitors (ICI) have revolutionized the treatment of solid
tumors with dramatic and durable responses seen across multiple tumor types. However …

Tumor mutational burden correlates with response to immune checkpoint blockade in
multiple solid tumors, although in microsatellite-stable tumors this association is of uncertain …

Recent clinical successes with immunotherapy have resulted in expanding indications for
cancer therapy. To enhance antitumor immune responses, and to better choose specific …