Rationale: Airway mucous cell metaplasia and chronic inflammation are pathophysiological
features that influence morbidity and mortality associated with asthma and other chronic …

Thyroid transcription factor-1 (TTF-1), a member of the Nkx2 family of homeodomain-
containing transcription factors, is expressed in the epithelium of the lung. TTF-1 is a critical …

Rationale: Increased production of mucus is a prominent feature of asthma. IL-13–driven
mucous cell metaplasia is associated with decreased expression of the transcription factor …

Therapeutic targets in asthma are reduction of airway inflammation and remodelling, the
latter is not affected by available drugs. Here we present data that inhibition of MAPK …

The homeodomain transcription factor Nkx2-1 is essential for normal lung development and
homeostasis. In lung tumors, it is considered a lineage survival oncogene and prognostic …

Targeting airway goblet cell metaplasia is a novel strategy that can potentially reduce the
chronic obstructive pulmonary disease (COPD) symptoms. Tumor suppressor liver kinase …

In response to inflammation or injury, airway epithelial cells express inducible genes that
may contribute to allergen-induced airway remodeling. To determine the contribution of …

Thyroid transcription factor-1 (TTF-1/Nkx2. 1/TITF1) is a homeodomain-containing
transcription factor essential for the morphogenesis and differentiation of the lung. In the …

Purpose Chronic rhinosinusitis (CRS) is characterized by the excessive production of
mucus. However, the molecular mechanism underlying mucin overproduction in CRS with or …

Chronic airway disorders, including chronic obstructive pulmonary disease (COPD), cystic
fibrosis, and asthma, are associated with persistent pulmonary inflammation and goblet cell …