Gene map of the extended human MHC

R Horton, L Wilming, V Rand, RC Lovering… - Nature Reviews …, 2004 - nature.com
The major histocompatibility complex (MHC) is the most important region in the vertebrate
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …

Human MHC architecture and evolution: implications for disease association studies

JA Traherne - International journal of immunogenetics, 2008 - Wiley Online Library
Major histocompatibility complex (MHC) variation is a key determinant of susceptibility and
resistance to a large number of infectious, autoimmune and other diseases. Identification of …

Genomic Organization of the Mammalian Mhc

A Kumánovics, T Takada… - Annual review of …, 2003 - annualreviews.org
The Human Genome Project transformed the quest of more than 50 years to understand the
major histocompatibility complex (Mhc). The sequence of the Mhc from human and mouse …

Major histocompatibility complex genomics and human disease

J Trowsdale, JC Knight - Annual review of genomics and human …, 2013 - annualreviews.org
Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

[HTML][HTML] Defining the role of the MHC in autoimmunity: a review and pooled analysis

MMA Fernando, CR Stevens, EC Walsh… - PLoS …, 2008 - journals.plos.org
The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …

[HTML][HTML] The MHC locus and genetic susceptibility to autoimmune and infectious diseases

V Matzaraki, V Kumar, C Wijmenga, A Zhernakova - Genome biology, 2017 - Springer
In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also
known as the human leukocyte antigen (HLA), have been reported as major risk factors for …

The human Major Histocompatibility Complex as a paradigm in genomics research

C Vandiedonck, JC Knight - Briefings in Functional Genomics …, 2009 - academic.oup.com
Since its discovery more than 50 years ago, the human Major Histocompatibility Complex
(MHC) on chromosome 6p21. 3 has been at the forefront of human genetic research. Here …

Comparative genomics of the human, macaque and mouse major histocompatibility complex

T Shiina, A Blancher, H Inoko, JK Kulski - Immunology, 2017 - Wiley Online Library
The MHC is a highly polymorphic genomic region that encodes the transplantation and
immune regulatory molecules. It receives special attention for genetic investigation because …

[HTML][HTML] Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history

JA Traherne, R Horton, AN Roberts, MM Miretti… - PLoS …, 2006 - journals.plos.org
The major histocompatibility complex (MHC) is recognised as one of the most important
genetic regions in relation to common human disease. Advancement in identification of …

The nature of selection on the major histocompatibility complex

V Apanius, D Penn, PR Slev, LR Ruff… - Critical Reviews™ in …, 2017 - dl.begellhouse.com
Only natural selection can account for the extreme genetic diversity of genes of the major
histocompatibility complex (MHC). Although the structure and function of classic MHC genes …