In order to identify new markers of vascular cell senescence with potential in vivo
implications, primary cultured endothelial cells, including human umbilical vein endothelial …

A senescent phenotype in endothelial cells is associated with increased apoptosis, reduced
endothelial nitric oxide synthase (eNOS) and inflammation, which are implicated in arterial …

Ageing constitutes the biggest risk factor for poor health and adversely affects the integrity
and function of all the cells, tissues, and organs in the human body. Vascular ageing …

BACKGROUND: Increasing evidence has demonstrated that the senescence of vascular
endothelial cells has critical roles in the pathogenesis of vascular dysfunction such as …

Increasing evidence suggests that microRNAs (miRNAs) play important roles in impaired
endothelial cell (EC) angiogenesis during aging. However, their exact roles in the aging …

The functionality of endothelial cells is fundamental for the homoeostasis of the vascular
system. Increasing evidence shows that endothelial inflammation and senescence …

Vascular aging, a specific type of organic aging, is related to age‐dependent changes in the
vasculature, including atherosclerotic plaques, arterial stiffness, fibrosis, and increased …

Vascular endothelial senescence contributes to atherosclerosis and coronary artery disease
(CAD), but the mechanisms are yet to be clarified. We identified that microRNA‐216a (miR …

Aging is an important risk factor for the development of many cardiovascular diseases as
atherosclerosis and is accompanied by the decline of endothelial function. Senescence of …

Lipid dysfunction, inflammation, immune response and advanced aging are major factors
involved in the initiation and progression of atherosclerosis. MicroRNAs (miRNAs) have …