Voltage-dependent potassium, sodium and calcium ion channels may share a common
mechanism of activation, in which the conserved S4 sequence acts as the primary voltage …

THE voltage-activated K+, Na+ and Ca2+ channels are responsible for the generation and
propagation of electrical signals in cell membranes. The K+ channels are multimeric …

THE ability of ion-channel proteins to respond to a change of the transmembrane voltage is
one of the basic mechanisms underlying electrical excitability of nerve and muscle …

Potassium channels comprise a diverse class of ion channels important for neuronal
excitability and plasticity1, 2. The recent cloning of the Shaker locus from Drosophila …

CLONING and expression of voltage-activated potassium ion-channel complementary
DNAs1–4 has confirmed that these channels are composed of four identical subunits5, each …

Voltage-dependent ion channels respond to changes in the membrane potential by means
of charged voltage sensors intrinsic to the channel protein. Changes in transmembrane …

POTASSIUM channels show a wide range of functional diversity1–3. Nerve cells typically
express a number of K+. channels that differ in their kinetics, single-channel conductance …

THE sodium channel, one of the family of structurally homologous voltage-gated ion
channels1, differs from other members, such as the calcium and the potassium channels, in …

Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins
function as tetrameric assemblies of identical or similar subunits,,,. The clustering of four …

Voltage-sensitive membrane channels, the sodium channel, the potassium channel and the
calcium channel operate together to amplify, transmit and generate electric pulses in higher …