Herein we present an assay allowing concurrent detection of oxidative DNA damage and
photoproducts. We apply DNA repair enzymes specific for each lesion type to incorporate …

DNA damage and repair are linked to fundamental biological processes such as
metabolism, disease, and aging. Single-strand lesions are the most abundant form of DNA …

Knowing the amount and type of DNA damage is of great significance for a broad range of
clinical and research applications. However, existing methods are either lacking in their …

DNA damage is a natural consequence of daily life. Endogenous metabolism and
exposures to environmental, dietary, and therapeutic chemicals, create modified DNA bases …

Single-molecule fluorescence imaging of DNA-binding proteins has enabled detailed
investigations of their interactions. However, the intercalating dyes used to visually locate …

The repair of oxidative damage to DNA is essential to avoid mutations that lead to cancer.
Oxidized DNA bases, such as 8‐oxoguanine, are a main source of these mutations, and the …

DNA repair is now understood to play a key role in a variety of disease states, most notably
cancer. Tools for studying DNA have typically relied on traditional biochemical methods …

The human nucleotide excision repair system targets a wide variety of DNA adducts for
removal from DNA, including photoproducts induced by UV wavelengths of sunlight. A key …

DNA damage seriously threats the genomic stability and is linked to mutagenesis,
carcinogenesis, and cell death. DNA damage includes the isolated damage and the …

The purine and pyrimidine bases in DNA are critical cellular targets of UV light and various
oxidizing agents and processes, including ion-izing radiation, photoexcited dyes, antibiotics …