Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
Dopamine modulates movement, cognition, and emotion through activation of dopamine G
protein–coupled receptors in the brain. The crystal structure of the human dopamine D3 …
protein–coupled receptors in the brain. The crystal structure of the human dopamine D3 …
Distinct functions of the two isoforms of dopamine D2 receptors
Signalling through dopamine D2 receptors governs physiological functions related to
locomotion, hormone production and drug abuse,,,,,,. D2 receptors are also known targets of …
locomotion, hormone production and drug abuse,,,,,,. D2 receptors are also known targets of …
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward,
addiction, control of coordinated movement, metabolism and hormonal secretion …
addiction, control of coordinated movement, metabolism and hormonal secretion …
Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist
Abstract Dopamine D1 receptor (D1R) is an important drug target implicated in many
psychiatric and neurological disorders. Selective agonism of D1R are sought to be the …
psychiatric and neurological disorders. Selective agonism of D1R are sought to be the …
Current perspectives on the selective regulation of dopamine D2 and D3 receptors
DI Cho, M Zheng, KM Kim - Archives of pharmacal research, 2010 - Springer
Among the characterized dopamine receptor subtypes, D 2 receptor (D 2 R) and D 3
receptor (D 3 R) are the main targets of neuroleptics that are currently in use. In particular, D …
receptor (D 3 R) are the main targets of neuroleptics that are currently in use. In particular, D …
Progress in developing D3 dopamine receptor ligands as potential therapeutic agents for neurological and neuropsychiatric disorders
RR Luedtke, RH Mach - Current pharmaceutical design, 2003 - ingentaconnect.com
The dopamine D3 receptor has been the subject of a tremendous amount of research since
its discovery in 1990. A previous review of this subject [3] described the advances in …
its discovery in 1990. A previous review of this subject [3] described the advances in …
Structures of the human dopamine D3 receptor-Gi complexes
The dopamine system, including five dopamine receptors (D1R–D5R), plays essential roles
in the central nervous system (CNS), and ligands that activate dopamine receptors have …
in the central nervous system (CNS), and ligands that activate dopamine receptors have …
The D3 dopamine receptor in cellular and organismal function
RA Shafer, B Levant - Psychopharmacology, 1998 - Springer
The D 3 dopamine receptor is a member of the family of D 2-like dopamine receptors. Since
the cloning and identification of the D 3 receptor in 1990, considerable progress has been …
the cloning and identification of the D 3 receptor in 1990, considerable progress has been …
Neuronal dopamine D3 receptors: translational implications for preclinical research and CNS disorders
B Kiss, I Laszlovszky, B Krámos, A Visegrády, A Bobok… - Biomolecules, 2021 - mdpi.com
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …
and periphery, exerts its actions through five types of receptors which belong to two major …
Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine
The human dopamine D4 receptor (D4R) has received considerable attention because of its
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …
high affinity for the atypical antipsychotic clozapine and the unusually polymorphic nature of …