Partial cell reprogramming has been demonstrated in certain mouse tissues by in situ
overexpression of Oct3/4, Klf4, Sox2 and cMyc (OKSM) transcription factors, and can trigger …

Partial cell reprogramming has been demonstrated in certain mouse tissues by in situ
overexpression of Oct3/4, Klf4, Sox2 and cMyc (OKSM) transcription factors, and can induce …

In contrast to mammals, lower vertebrates are capable of extraordinary myocardial
regeneration thanks to the ability of their cardiomyocytes to undergo transient …

Cellular reprogramming has rapidly become a promising methodology to generate new
cardiomyocytes from non-cardiomyocyte cell types. Using the transient expression of OSKM …

Cardiomyocytes are critically responsible for heart contraction and the pumping of blood
through the circulatory system. In adult mice and humans, the rate of cardiomyocyte division …

Zebrafish and urodele amphibians are capable of extraordinary myocardial regeneration
thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and …

Cardiomyocyte (CM) replacement is very slow in adult mammalian hearts, preventing
regeneration of damaged myocardium. By contrast, fetal hearts display considerable …

Here we show that conventional reprogramming towards pluripotency through
overexpression of Oct4, Sox2, Klf4 and c-Myc can be shortcut and directed towards …

expanded from cardiac biopsies by different protocols. 9, 10 Very recently, the first patients
were treated with either cardiosphere-derived cardiac stem cells (CArdiosphere-Derived …

The induction of in vivo reprogramming toward pluripotency has been demonstrated in
several tissues utilizing either transgenic inducible mice or gene delivery approaches …