Sažetak The objective of the present study was to develop a robust, simple, economical and
sensitive HPLC-UV method using the “quality-by-design” approach for the estimation of …

A simple and rapid reverse phase high performance liquid chromatography (RP‐HPLC)
method was developed and validated for quantitative determination of irinotecan in bulk …

Irinotecan (IRI) is an antineoplastic drug widely used for the treatment of colorectal and
advanced pancreatic cancer. Despite its clinical utility, the clinical use of IRI is associated …

Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC).
This drug has a narrow therapeutic range and treatment can lead to side effects, mainly …

A new, simple, sensitive and specific reversed-phase high performance liquid
chromatographic (HPLC) method using ultraviolet detection was developed and validated …

Abstract Irinotecan (CPT-11) is an anticancer drug with a complex in vivo metabolism widely
used in the treatment of colon cancer. The assessment of the CPT-11 metabolic phenotype …

Background: We developed gradient HPLC methods for quantification of the antimitotic drug
irinotecan (CPT-11) and its four metabolites, SN-38, SN-38 G, 7-ethyl-10-[4-N-(5 …

Abstract Irinotecan (CPT-11) is a novel topoisomerase I inhibitor with clinical activity in
human malignancies. The objective of this study was to develop efficient limited sampling …

The objective of this research is to develop and validate a sensitive and reproducible UPLC–
MS/MS method to quantify irinotecan, its active metabolite SN-38 and SN-38 glucuronide …

Objectives Our objective was to build population pharmacokinetic models that describe
plasma concentrations of irinotecan (CPT‐11) and its metabolites 7‐ethyl‐10 …