Cognitive impairment is one of the most important negative consequences associated with
cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation …

Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

Marijuana impairs learning and memory through actions of its psychoactive constituent,
delta-9-tetrahydrocannabinol (Δ9-THC), in the hippocampus, through activation of …

Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the
modulation of endogenous cannabinoids, affect cognitive function through the activation of …

Considerable evidence demonstrates that cannabinoid agonists impair whereas
cannabinoid antagonists improve memory and plasticity. However, recent studies suggest …

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in
learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9 …

Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral …

Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the most prominent active constituent
of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult …

Cannabinoids impair hippocampus-dependent memory in both humans and animals, but
the network mechanisms responsible for this effect are unknown. Here we show that the …

Cannabis use is associated with a wide range of pharmacological effects, some of which
have potential therapeutic benefit while others result in negative outcomes. Acute …