Whereas dopamine agonists are known to provide symptomatic benefits for Parkinson's
disease, recent clinical trials suggest that they might also be neuroprotective. Laboratory …

Accurate control of dopamine levels and/or the resulting dopamine–receptor interaction is
essential for brain function. Indeed, several human neurological and psychiatric disorders …

Bromocriptine, acting through the dopamine D 2 receptor, provides robust protection against
apoptosis induced by oxidative stress in PC12-D 2 R and immortalized nigral dopamine …

Dopamine (DA), through D1/D2 receptor-mediated signaling, plays a major role in the
control of epileptic seizures arising in the limbic system. Excitotoxicity leading to neuronal …

Neuroinflammation involves the activation of glial cells, which is associated to the
progression of neurodegeneration in Parkinson's disease. Recently, we and other …

Several neurotransmitters that act through G protein-linked receptors have been shown to
affect the growth rate of dividing cells. An analysis of the early signaling events that mediate …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that results in major
motor disturbances due primarily to loss of midbrain dopamine neurons. The mainstream …

In this study, in vitro and in vivo experiments were carried out with the high‐affinity
multifunctional D2/D3 agonist D‐512 to explore its potential neuroprotective effects in …

An increase in dopamine (DA) availability in rat brain has been suggested to participate in
certain neurodegenerative processes. However, the regulatory effects of DA on glial cells …

Accumulated evidence suggests that dopamine and dopamine D1agonists can activate
phospholipase C in both brain and peripheral tissue. The receptor that mediates the …