Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …

Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with
body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of …

Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …

Obesity results from the interaction of genetic and environmental factors. To search for
sequence variants that affect variation in two common measures of obesity, weight and body …

Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

Multiple biological, behavioural and genetic determinants or correlates of obesity have been
identified to date. Genome-wide association studies (GWAS) have contributed to the …

The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Muller et al. have provided a strong critique of the Genome-Wide Association Studies
(GWAS) of body-mass index (BMI), arguing that the GWAS approach for the study of BMI is …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …