The genetic architecture of the human cerebral cortex
KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Genetic complexity of cortical structure: differences in genetic and environmental factors influencing cortical surface area and thickness
Quantifying the genetic architecture of the cerebral cortex is necessary for understanding
disease and changes to the brain across the lifespan. Prior work shows that both surface …
disease and changes to the brain across the lifespan. Prior work shows that both surface …
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
NL Jorstad, J Close, N Johansen, AM Yanny… - Science, 2023 - science.org
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We
used single cell transcriptomics and performed cellular characterization of the human cortex …
used single cell transcriptomics and performed cellular characterization of the human cortex …
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
Cortical thickness is influenced by regionally specific genetic factors
BACKGROUND: Although global brain structure is highly heritable, there is still variability in
the magnitude of genetic influences on the size of specific regions. Yet, little is known about …
the magnitude of genetic influences on the size of specific regions. Yet, little is known about …
[HTML][HTML] Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology
Brain morphology has been shown to be highly heritable, yet only a small portion of the
heritability is explained by the genetic variants discovered so far. Here we extended the …
heritability is explained by the genetic variants discovered so far. Here we extended the …
Genetic topography of brain morphology
Animal data show that cortical development is initially patterned by genetic gradients largely
along three orthogonal axes. We previously reported differences in genetic influences on …
along three orthogonal axes. We previously reported differences in genetic influences on …
Patterning and plasticity of the cerebral cortex
M Sur, JLR Rubenstein - Science, 2005 - science.org
The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into
discrete subdivisions or areas that process particular aspects of sensation, movement, and …
discrete subdivisions or areas that process particular aspects of sensation, movement, and …