Context Global DNA hypomethylation is a major event for the development and progression
of cancer, although the significance in thyroid cancer remains unclear. Therefore, we aimed …

Thyroid cancer is a heterogeneous disease with several subtypes characterized by
cytological, histological and genetic alterations, but the involvement of epigenetics is not …

Anaplastic thyroid cancer (ATC) is one of the most malignant tumors, with a median survival
of only a few months. The tumorigenic processes of this disease have not yet been …

Background: There are no reliable biomarkers to accurately differentiate indolent thyroid
tumors from more aggressive thyroid cancers. This study aimed to develop new DNA …

Background: During development, methylation permanently changes gene activity, while
aberrant gene methylation is key to human tumorigenesis. Gene methylation is an …

Cancer arises through accumulation of epigenetic and genetic alteration. Aberrant promoter
methylation is a common epigenetic mechanism of gene silencing in cancer cells. We here …

Objective: The purpose of this study was to determine the global patterns of aberrant DNA
methylation in thyroid cancer. Research Design and Methods: We have used DNA …

Purpose While global hypomethylation of DNA has been found in several malignancies,
studies on thyroid tumours have shown controversial results using different techniques. To …

Context Even though the majority of well-differentiated thyroid carcinoma (WDTC) is
indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests …

In recent years, cancer genomics has provided new insights into genetic alterations and
signaling pathways involved in thyroid cancer. However, the picture of the molecular …