Caffeine modulates cadmium-induced oxidative stress, neuroinflammation, and cognitive impairments by regulating Nrf-2/HO-1 in vivo and in vitro

A Khan, M Ikram, T Muhammad, J Park… - Journal of Clinical …, 2019 - mdpi.com
Cadmium (Cd), a nonbiodegradable heavy metal and one of the most neurotoxic
environmental and industrial pollutants, promotes disturbances in major organs and tissues …

Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK …

R Hao, X Song, F Li, X Tan, D Sun-Waterhouse… - Food and Chemical …, 2020 - Elsevier
Exposure to nonbiodegradable cadmium (Cd) causes many health problems including the
damage to the nervous system. This study aimed to increase knowledge about its neurotoxic …

Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats

C Unsal, M Kanter, C Aktas… - … and industrial health, 2015 - journals.sagepub.com
The present study was carried out to evaluate the neuroprotective effect of quercetin (QE) in
protecting the cadmium (Cd)-induced neuronal injury in frontal cortex of rats. A total of 30 …

Royal jelly mitigates cadmium-induced neuronal damage in mouse cortex

RS Almeer, RB Kassab, GI AlBasher, S Alarifi… - Molecular biology …, 2019 - Springer
This study aimed to evaluate the potential neuroprotective effect of royal jelly (RJ) against
Cd-induced neuronal damage. Twenty-eight adult mice were placed equally into four …

Curcumin ameliorates the Cd-induced anxiety-like behavior in mice by regulating oxidative stress and neuro-inflammatory proteins in the prefrontal cortex region of …

D Namgyal, S Ali, MD Hussain, M Kazi, A Ahmad… - Antioxidants, 2021 - mdpi.com
Age-related neurodegenerative diseases and vascular dementia are major challenges to
the modern health care system. Most neurodegenerative diseases are associated with …

Protocatechuic acid mitigates cadmium-induced neurotoxicity in rats: Role of oxidative stress, inflammation and apoptosis

EM Al Olayan, AS Aloufi, OD AlAmri, H Ola… - Science of the total …, 2020 - Elsevier
Environmental and occupational exposure to heavy metals, including cadmium (Cd), is
associated with extremely adverse impacts to living systems. Antioxidant agents are …

Quercetin attenuates manganese-induced neuroinflammation by alleviating oxidative stress through regulation of apoptosis, iNOS/NF-κB and HO-1/Nrf2 pathways

E Bahar, JY Kim, H Yoon - International journal of molecular sciences, 2017 - mdpi.com
Manganese (Mn) is an essential trace element required for the development of human body
and acts as an enzyme co-factor or activator for various reactions of metabolism. While …

Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress

DG Mostafa, EF Khaleel, RM Badi… - Neurological …, 2019 - Taylor & Francis
Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated
with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum …

Potential of quercetin to protect cadmium induced cognitive deficits in rats by modulating NMDA-R mediated downstream signaling and PI3K/AKT—Nrf2/ARE …

A Srivastava, A Kumari, P Jagdale, A Ayanur… - NeuroMolecular …, 2023 - Springer
Exposure to cadmium, a heavy metal distributed in the environment is a cause of concern
due to associated health effects in population around the world. Continuing with the leads …

Protective role of quercetin in cadmium-induced cholinergic dysfunctions in rat brain by modulating mitochondrial integrity and MAP kinase signaling

R Gupta, RK Shukla, LP Chandravanshi… - Molecular …, 2017 - Springer
With the increasing evidences of cadmium-induced cognitive deficits associated with brain
cholinergic dysfunctions, the present study aimed to decipher molecular mechanisms …