Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic …

MA Nauck, MM Heimesaat, KAI Behle… - The Journal of …, 2002 - academic.oup.com
Glucagon-like peptide 1 (GLP-1) and analogues are being evaluated as a new therapeutic
principle for the treatment of type 2 diabetes. GLP-1 suppresses glucagon secretion, which …

GLP-1 does not acutely affect insulin sensitivity in healthy man

L Ørskov, JJ Holst, J Møller, C Ørskov, N Møller… - Diabetologia, 1996 - Springer
Previous studies have suggested that glucagon-like peptide-1 (GLP-1)(7–36 amide) may
have the direct effect of increasing insulin sensitivity in healthy man. To evaluate this …

Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus

KJ Hare, FK Knop, M Asmar, S Madsbad… - The Journal of …, 2009 - academic.oup.com
Objective: Glucagon-like peptide-1 (GLP-1) is insulinotropic, but its effect on the α-cell is less
clear. We investigated the dose-response relationship for GLP-1-induced glucagon …

Glucagon‐like peptide‐1 (GLP‐1): a trial of treatment in non‐insulin‐dependent diabetes mellitus

JF Todd, JPH Wilding, CMB Edwards… - European journal of …, 1997 - Wiley Online Library
Glucagon‐like peptide‐1 (7–36) amide (GLP‐1) is released from the gut into the circulation
after meals and is the most potent physiological insulinotropic hormone in man. In contrast to …

Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes

MB Toft-Nielsen, S Madsbad… - The Journal of Clinical …, 2001 - academic.oup.com
GLP-1 lowers blood glucose in fasting type 2 diabetic patients. To clarify the relation of the
effect of GLP-1 to obesity, blood glucose, β-cell function, and insulin sensitivity, GLP-1 (1.2 …

The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

KJ Hare, T Vilsbøll, M Asmar, CF Deacon, FK Knop… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Glucagon-like peptide 1 (GLP-1) exerts beneficial antidiabetic actions via
effects on pancreatic β-and α-cells. Previous studies have focused on the improvements in β …

Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus

B Ahren, H Larsson, JJ Holst - The Journal of Clinical …, 1997 - academic.oup.com
Administration of the truncated glucagon-like peptide 1 (GLP-1) has been considered for
treatment of noninsulin-dependent diabetes mellitus (NIDDM). We studied its …

Glucagon-like peptide 1 improved glycemic control in type 1 diabetes

MT Behme, J Dupré, TJ McDonald - BMC endocrine disorders, 2003 - Springer
Abstract Background Glucagon-like peptide-1 (GLP-1) and its agonists are under
assessment in treatment of type 2 diabetes, by virtue of their antidiabetic actions, which …

Effect of glucagon-like peptide 1 (7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes.

A Vella, P Shah, R Basu, A Basu, JJ Holst, RA Rizza - Diabetes, 2000 - Am Diabetes Assoc
Although it is well established that glucagon-like peptide 1 (7-36) amide (GLP-1) is a potent
stimulator of insulin secretion, its effects on insulin action and glucose effectiveness are less …

Insulinotropic hormone glucagon-like peptide-1-(7–37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia

AS Ryan, JM Egan, JF Habener… - The Journal of Clinical …, 1998 - academic.oup.com
Glucagon-like peptide-1 (GLP-1) is an intestinal insulinotropic hormone that augments
insulin secretion in response to meals and lowers blood glucose levels in both type 1 and …