Acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained
by a subset of self-renewing leukemia stem cells (LSC). We hypothesized that increased …

Background: CD47 is a transmembrane protein ubiquitously expressed in human cells.
CD47 is overexpressed in various malignancies and is correlated with negative prognosis in …

Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and
constitutes 15% of adult leukemias. Although overall prognosis for pediatric ALL is …

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by
nearly all cells of the body. It plays an integral role in various immune responses as well as …

CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis
mediated by cells of the innate immune system, such as macrophages and dendritic cells …

Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

CD47, a broadly expressed cell surface protein, inhibits cell phagocytosis via interaction
with phagocyte-expressed SIRPα. A variety of hematological malignancies demonstrate …

CD47 is a potent 'do not eat me'signal that enables cancer cells to evade detection by the
innate immune system, thereby avoiding destruction by first responder cells, such as …

Macrophages clear pathogens and damaged or aged cells from the blood stream via
phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPα, to …

Aberrant proliferation, symmetric self-renewal, increased survival, and defective
differentiation of malignant blasts are key oncogenic drivers in acute myeloid leukemia …