Development and validation of a LC–MS/MS method for the determination of ilaprazole enantiomers and its application to a bioequivalence study in healthy Chinese …

Z Tan, Y Wang, Y Chen, D Guo, S Cao, W Zhang… - Chromatographia, 2012 - Springer
A sensitive and specific liquid chromatography–electrospray ionization–mass spectrometry
method has been developed and validated for the identification and quantification of …

[HTML][HTML] Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application

F Ou, Y Zhou, J Lei, S Zeng, F Wu, N Zhang… - Journal of Pharmaceutical …, 2020 - Elsevier
Abstract In Korea and China, ilaprazole is a widely used proton pump inhibitor in the
treatment of gastric ulcers. In this study, a specific and sensitive LC-MS/MS method has …

An improved LC-MS/MS method for quantitative determination of ilaprazole and its metabolites in human plasma and its application to a pharmacokinetic study

G Zhou, Z Tan, W Zhang, D Ou-Yang, Y Chen… - Acta Pharmacologica …, 2009 - nature.com
Aim: To improve and validate an analytical method based on liquid chromatography and
electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the quantitative …

Enantioselective analysis of lansoprazole in rat plasma by LC–MS/MS: Application to a stereoselective pharmacokinetic study

L Luo, X Wen, Y Du, Z Jiang… - Biomedical …, 2018 - Wiley Online Library
A rapid, sensitive and enantioselective method was developed and fully validated for the
separation and determination of lansoprazole enantiomers in rat plasma by liquid …

Enantioselective determination of (R)‐ and (S)‐lansoprazole in human plasma by chiral liquid chromatography with mass spectrometry and its application to a …

L Sun, Y Cao, H Jiao, Y Fang, Z Yang… - Journal of separation …, 2015 - Wiley Online Library
A simple and enantioselective method was developed and validated for the simultaneous
determination of (R)‐and (S)‐lansoprazole in human plasma by chiral liquid …

Determination of lansoprazole enantiomers in dog plasma by column‐switching liquid chromatography with tandem mass spectrometry and its application to a …

H Wang, Y Sun, X Meng, B Yang… - Journal of separation …, 2015 - Wiley Online Library
Lansoprazole, a selective proton pump inhibitor, has a chiral benzimidazole sulfoxide
structure and is used for the treatment of gastric acid hypersecretory related diseases. To …

Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction

M Miura, H Tada, T Suzuki - Journal of Chromatography B, 2004 - Elsevier
A simple and highly sensitive high-performance liquid chromatography (HPLC) method for
the simultaneous quantitative determination of lansoprazole enantiomers and their …

Determination of ilaprazole in beagle plasma and its pharmaeokineties by high performance liquid chromatography-mass spectrometry

L Zhou, J Li, X Wang, J Qiao, Z Zhang - Se pu= Chinese Journal of …, 2012 - europepmc.org
A sensitive, simple and specific high performance liquid chromatography-electro spray
ionization mass spectrometry method was developed for the determination of ilaprazole in …

Development and validation of an enantioselective and chemoselective HPLC method using a Chiralpak IA column to simultaneously quantify (R)-(+)-and (S)-(−) …

R Cirilli, R Ferretti, B Gallinella, L Turchetto… - … of pharmaceutical and …, 2009 - Elsevier
An accurate and reproducible high-performance liquid chromatographic (HPLC) method has
been developed and validated for the direct separation of individual enantiomers of …

Development of solid-phase extraction and HPLC method for simultaneous estimation of ilaprazole and glimepiride in rat plasma: Application to pharmacokinetic …

AP Dewani, AS Tripathi, PG Shelke… - Journal of …, 2017 - academic.oup.com
A novel, simple and mass spectrometry (MS) compatible high-performance liquid
chromatography (HPLC) method is reported for the simultaneous estimation of ilaprazole …