Combination of ginsenosides Rb2 and Rg3 promotes angiogenic phenotype of human endothelial cells via PI3K/akt and MAPK/ERK pathways

RJ Choi, SZ Mohamad Zobir… - Frontiers in …, 2021 - frontiersin.org
Shexiang Baoxin Pill (SBP) is an oral formulation of Chinese materia medica for the
treatment of angina pectoris. It displays pleiotropic roles in protecting the cardiovascular …

Chuanxiong improves angiogenesis via the PI3K/AKT/Ras/MAPK pathway based on network pharmacology and DESI-MSI metabolomics

X Cheng, X Yang, H Cui, B Zhang, K Chen… - Frontiers in …, 2023 - frontiersin.org
Introduction: Chuanxiong, a traditional Chinese medicine, has been proved to treat a variety
of cardiovascular and cerebrovascular diseases by promoting angiogenesis. However, the …

[HTML][HTML] Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification

L Hou, Z Zou, Y Wang, H Pi, Z Yuan, Q He… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Ginsenoside Rb1 is the major active constituent of ginseng, which is widely used in
traditional Chinese medicine for the atherosclerosis treatment by anti-inflammatory, anti …

Ginsenoside-Rb1-Mediated Anti-angiogenesis via Regulating PEDF and miR-33a through the Activation of PPAR-γ Pathway

H Lu, X Zhou, HH Kwok, M Dong, Z Liu… - Frontiers in …, 2017 - frontiersin.org
Angiogenesis is the formation of new blood vessels from the existing vasculature, which is
involved in multiple biological processes, including atherosclerosis, ischemic heart disease …

Ginsenoside Rh1 inhibits angiotensin II-induced vascular smooth muscle cell migration and proliferation through suppression of the ROS-mediated ERK1/2/p90RSK …

DTN Huynh, Y Jin, D Van Nguyen, CS Myung, KS Heo - Antioxidants, 2022 - mdpi.com
Vascular smooth muscle cell (VSMC) proliferation and migration play key roles in the
progression of atherosclerosis and restenosis. A variety of ginsenosides exert various …

Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and β-catenin/T …

KW Leung, YL Pon, RNS Wong, AST Wong - Journal of Biological …, 2006 - ASBMB
Ginsenoside-Rg1, the most prevalent active constituent of ginseng, is a potent
proangiogenic factor of vascular endothelial cells. This suggests that Rg1 may be a new …

Pro-angiogenic ginsenosides F1 and Rh1 inhibit vascular leakage by modulating NR4A1

JI Kang, Y Choi, CH Cui, D Lee, SC Kim, HM Kim - Scientific reports, 2019 - nature.com
Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis, but VEGF-
induced angiogenesis is often accompanied by a vascular permeability response …

Pro-angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cells in vitro and in a chemical-induced blood vessel loss model of zebrafish in vivo

B Yang, S Hong, SMY Lee, W Cong, J Wan… - Chinese journal of …, 2016 - Springer
Objective This study aimed at investigating whether notoginsenoside R1 (R1), a unique
saponin found in Panax notoginseng could promote angiogenic activity on human umbilical …

Ginsenoside Rb3 Inhibits Angiotensin II‐Induced Vascular Smooth Muscle Cells Proliferation

T Wang, XF Yu, SC Qu, HL Xu… - Basic & clinical …, 2010 - Wiley Online Library
This study was designed to examine the effect of ginsenoside Rb3 on angiotensin (Ang) II‐
induced proliferation of cultured rat vascular smooth muscle cells (VSMCs). VSMCs …

Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation

YL Cho, SM Hur, JY Kim, JH Kim, DK Lee… - Journal of Biological …, 2015 - ASBMB
Ginsenoside Rg5 is a compound newly synthesized during the steaming process of
ginseng; however, its biological activity has not been elucidated with regard to endothelial …