Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens
Most variants associated with complex traits and diseases identified by genome-wide
association studies (GWAS) map to noncoding regions of the genome with unknown effects …
association studies (GWAS) map to noncoding regions of the genome with unknown effects …
[HTML][HTML] Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …
and environmental risk factors that disproportionately afflicts communities of color …
[PDF][PDF] Taiwan Biobank: A rich biomedical research database of the Taiwanese population
Summary The Taiwan Biobank (TWB) is an ongoing prospective study of> 150,000
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
individuals aged 20–70 in Taiwan. A comprehensive list of phenotypes was collected for …
[PDF][PDF] Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits
Genome-wide association studies (GWAS) on diverse ancestry groups are lacking, resulting
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …
in deficits of genetic discoveries and polygenic scores. We conducted GWAS for 76 …
Genetically predicted differences in systolic blood pressure and risk of cardiovascular and noncardiovascular diseases: a Mendelian Randomization Study in Chinese …
Background: Mendelian randomization studies of systolic blood pressure (SBP) can assess
the shape and strength of the associations of genetically predicted differences in SBP with …
the shape and strength of the associations of genetically predicted differences in SBP with …
[HTML][HTML] Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases
Genome-wide association studies (GWAS) of human complex traits or diseases often
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
Associations between body mass index, WNT16 rs2908004 and osteoporosis: findings from Taiwan biobank
CL Wu, ON Nfor, DM Tantoh, WY Lu… - Journal of …, 2022 - Taylor & Francis
Purpose Osteoporosis is a degenerative disease that affects women and men of all races.
We studied the association between body mass index (BMI), rs2908004 polymorphism of …
We studied the association between body mass index (BMI), rs2908004 polymorphism of …
Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults
Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD).
Genome-wide association studies (GWAS) conducted predominantly in populations of …
Genome-wide association studies (GWAS) conducted predominantly in populations of …
Validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
ABSTRACT Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and
environmental risk factors that disproportionately afflicts communities of color. Leveraging …
environmental risk factors that disproportionately afflicts communities of color. Leveraging …