DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …

The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many
of which are typified by neurological dysfunction and/or increased genetic instability and …

Juvenile amyotrophic lateral sclerosis (ALS4) is a rare autosomal dominant form of juvenile
amyotrophic lateral sclerosis (ALS) characterized by distal muscle weakness and atrophy …

The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental
analysis of this fascinating protein is still unveiling new insights into the DNA damage …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Abstract Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs covalently bound topoisomerase
I–DNA complexes 1, 2, 3 and is essential for preventing the formation of double-strand …

An updated inventory of about 150 human DNA repair genes is described. The compilation
includes genes encoding DNA repair enzymes, some genes associated with cellular …