Spatial components of molecular tissue biology
Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …
evolving, making it possible to comprehensively characterize cells and tissues in health and …
Multi-omics integration in the age of million single-cell data
An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
heterogeneity of cell types and novel cell-state associations with sex, disease, development …
Integration of whole transcriptome spatial profiling with protein markers
Spatial transcriptomics and proteomics provide complementary information that
independently transformed our understanding of complex biological processes. However …
independently transformed our understanding of complex biological processes. However …
[PDF][PDF] Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin
Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment.
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …
CAFs were once thought to be a relatively uniform population of matrix-producing cells, but …
Spatial omics: Navigating to the golden era of cancer research
Y Wu, Y Cheng, X Wang, J Fan… - Clinical and Translational …, 2022 - Wiley Online Library
The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …
surprise many cancer biologists; however, systematically capturing spatial architecture of …
[HTML][HTML] Robust single-cell matching and multimodal analysis using shared and distinct features
The ability to align individual cellular information from multiple experimental sources is
fundamental for a systems-level understanding of biological processes. However, currently …
fundamental for a systems-level understanding of biological processes. However, currently …
[HTML][HTML] Normalizing and denoising protein expression data from droplet-based single cell profiling
MP Mulè, AJ Martins, JS Tsang - Nature communications, 2022 - nature.com
Multimodal single-cell profiling methods that measure protein expression with oligo-
conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity …
conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity …
[HTML][HTML] Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells
Background Autologous T cells engineered to express a chimeric antigen receptor (CAR)
specific for CD19 molecule have transformed the therapeutic landscape in patients with …
specific for CD19 molecule have transformed the therapeutic landscape in patients with …
[HTML][HTML] Unraveling the complexity of the cancer microenvironment with multidimensional genomic and cytometric technologies
NL De Vries, A Mahfouz, F Koning… - Frontiers in …, 2020 - frontiersin.org
Cancers are characterized by extensive heterogeneity that occurs intratumorally, between
lesions, and across patients. To study cancer as a complex biological system …
lesions, and across patients. To study cancer as a complex biological system …
Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome
A Bettiol, M Becatti, E Silvestri… - Clinical & …, 2021 - academic.oup.com
Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …